GWAS-related eQTLs across different cancer types
We identified 337,131 eQTLs that overlap with GWAS linkage disequilibrium (LD) regions (r² ≥ 0.5).
|
Cancer type
|
eQTL type
|
tagSNP
|
Gene position (hg19)
|
p-value
|
|||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| BRCA | cis | rs1056667 | 1 | rs10946834 | chr6:26533664 | BTN2A3 | chr6:26422317-26431927:+ | 0.16 | 5.51 | 4.58E-8 | Educational attainment |
| BRCA | cis | rs1056667 | 1 | rs10946834 | chr6:26533664 | C6orf41 | chr6:26924772-26991752:+ | -0.12 | -3.7 | 0.000227 | Educational attainment |
| BRCA | cis | rs1056667 | 1 | rs10946834 | chr6:26533664 | ZNF322A | chr6:26634612-26659963:- | -0.1 | -3.5 | 0.000489 | Educational attainment |
| BRCA | cis | rs1056667 | 1 | rs10946835 | chr6:26533757 | BTN2A3 | chr6:26422317-26431927:+ | 0.16 | 5.51 | 4.58E-8 | Educational attainment |
| BRCA | cis | rs1056667 | 1 | rs10946835 | chr6:26533757 | C6orf41 | chr6:26924772-26991752:+ | -0.12 | -3.7 | 0.000227 | Educational attainment |
| BRCA | cis | rs1056667 | 1 | rs10946835 | chr6:26533757 | ZNF322A | chr6:26634612-26659963:- | -0.1 | -3.5 | 0.000489 | Educational attainment |
| BRCA | cis | rs904251 | 1 | rs10947673 | chr6:37445079 | C6orf129 | chr6:37450699-37467700:- | 0.12 | 4.85 | 1.39E-6 | Cognitive performance |
| BRCA | cis | rs904251 | 1 | rs10947673 | chr6:37445079 | RNF8 | chr6:37321748-37362513:+ | 0.13 | 3.76 | 0.00018 | Cognitive performance |
| BRCA | cis | rs12196860 | 1 | rs10948974 | chr6:55992520 | COL21A1 | chr6:55921389-56258892:- | -0.38 | -6.98 | 5.28E-12 | Psychosis (atypical) |
| BRCA | cis | rs12196860 | 1 | rs10948975 | chr6:55992744 | COL21A1 | chr6:55921389-56258892:- | -0.38 | -6.98 | 5.28E-12 | Psychosis (atypical) |
| BRCA | cis | rs2243480 | 1 | rs10950032 | chr7:65738591 | CCT6P1 | chr7:65216092-65228661:+ | -0.31 | -6.63 | 5.22E-11 | Diabetic kidney disease |
| BRCA | cis | rs2243480 | 1 | rs10950032 | chr7:65738591 | CRCP | chr7:65579805-65619551:+ | 0.21 | 3.49 | 0.000501 | Diabetic kidney disease |
| BRCA | cis | rs2243480 | 1 | rs10950032 | chr7:65738591 | LOC493754 | chr7:65993446-66057363:- | -0.24 | -4.03 | 5.97E-5 | Diabetic kidney disease |
| BRCA | cis | rs67250450 | 1 | rs10951192 | chr7:28161033 | JAZF1 | chr7:27870196-28220437:- | -0.13 | -4.64 | 3.93E-6 | Rheumatoid arthritis |
| BRCA | cis | rs10808739 | 1 | rs10957322 | chr8:65670364 | CYP7B1 | chr8:65508529-65711348:- | 0.12 | 3.83 | 0.000136 | HIV-1 susceptibility |